ABOUT Amy
Despite the therapeutic relevance of many human protein phosphatases, our understanding of their biological substrates, substrate selectivity, cellular regulation and druggability is limited. Research in the Barrios lab focuses on addressing these challenges through the development and application of novel chemical probes,
1) using fluorogenic probes to investigate protein phosphatase activity and regulation during cellular signaling,
2) identifying protein phosphatase inhibitors for use as therapeutic lead compounds
3) investigating the impact of protein phosphorylation on structure and function.
We are particularly interested in protein phosphatases involved in immune system dysregulation, cancer, and neurological disease.
Education:
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B.S. 1995, Chemistry, University of Utah
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Ph.D. 2000, Massachusetts Institute of Technology. Mentor: Stephen J. Lippard
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2000-2003, Department of Pharmaceutical Chemistry, University of California, San Francisco, NIH Postdoctoral Fellow. Mentor: Charles S. Craik
Awards & Nominations:
All the awards. All of them.
Meet the Team
Barrios lab members
