Publications

Brandon S. McCullough, Hanfei Wang, and Amy M. Barrios. (2022).

Inhibitor Screen Identifies Covalent Inhibitors of the Protein Histidine

Phosphatase PHPT1. ACS Medicinal Chemistry Letters

13 (7), 1198-1201 DOI: 10.1021/a

csmedchemlett.2c00053

Matthew R. Blake, Ryan T. Gardner, Haihong Jin, Melanie A. Staffenson,

Nicole J. Rueb, Amy M. Barrios, Gregory B. Dudley, Michael S. Cohen*,

and Beth A. Habecker. (2022). Small Molecules Targeting PTPσ–Trk

Interactions Promote Sympathetic Nerve Regeneration. ACS Chemical

Neuroscience, 13(5), 688-699.

Harvey F. Fulo, Nicole J. Rueb, Robert Gaston, Paratchata Batsomboon,

Kh Tanvir Ahmed, Amy M. Barrios, Gregory B. Dudley. (2021). Synthesis of

illudalic acid and analogous phosphatase inhibitors. Organic and

Biomolecular Chemistry, doi: 10.1039/D1OB02106K

Cheryl L. Mathis, Amy M. Barrios. (2021). Histidine phosphorylation

in metalloprotein binding sites. Journal of Inorganic Biochemistry,

225:111606-. doi: 10.1016/J.JINORGBIO.2021.111606

Amy M. Barrios. (2020). PTPs: Degrading the Undruggable. Journal of Medicinal Chemistry, 63(14):7508-7509. doi: 10.1021/ACS.JMEDCHEM.0C01000

Brandon S. McCullough, Amy M. Barrios. (2020). Fluorogenic probes for imaging cellular phosphatase activity. Current Opinion in Chemical Biology, 57:34-40. doi: 10.1016/J.CBPA.2020.04.004

Brandon S. McCullough, Amy M. Barrios. (2019). In Vitro Assays for Measuring Protein Histidine Phosphatase Activity. Methods of Molecular Biology, 2077:109-120. doi: 10.1007/978-1-4939-9884-5_8

Brandon S. McCullough, Paratchata Batsomboon, Kacey B. Hutchinson, Gregory B. Dudley, Amy M. Barrios. (2019). Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions. Journal of Natural Products, 82(12):3386-3393. doi: 10.1021/ACS.JNATPROD.9B00663

Elena S. Ma, Amy M. Barrios. (2019). Rational design of a SHP-2 targeted, fluorogenic peptide substrate. Bioorganic & Medicinal Chemistry Letters, 29(17):2452-2454. doi: 10.1016/J.BMCL.2019.07.034

Brandon S. McCullough, Amy M. Barrios. (2018). Facile, Fluorogenic Assay for Protein Histidine Phosphatase Activity. Biochemistry, 57(18):2584-2589. doi: 10.1021/ACS.BIOCHEM.8B00278

Margaret L. Aulsebrook, Suvendu Biswas, Franklin M. Leaver, Michael R. Grace, Bim Graham, Amy M. Barrios, Kellie L. Tuck. (2017). A luminogenic lanthanide-based probe for the highly selective detection of nanomolar sulfide levels in aqueous samples. Chemical Communications, 53(36):4911-4914. doi: 10.1039/C7CC01764B

Suvendu Biswas, Brandon S. McCullough, Elena S. Ma, Dollie LaJoie, Colin W. Russell, D. Garrett Brown, June L. Round, Katharine S. Ullman, Matthew A. Mulvey, Amy M. Barrios. (2017). Dual colorimetric and fluorogenic probes for visualizing tyrosine phosphatase activity. Chemical Communications, 53(14):2233-2236. doi: 10.1039/C6CC09204G

Amy M. Barrios, Megan K. Thorson, Kellie L. Tuck, Graham Bim. (2016). Chemical probes for hydrogen sulfide.

Megan K. Thorson, Phuc, Ung, Franklin, M, Leaver, Teresa, S, Corbin, Kellie L. Tuck, Bim Graham, Amy M. Barrios. (2015). Lanthanide complexes as luminogenic probes to measure sulfide levels in industrial samples. Analytica Chimica Acta, 896:160-165. doi: 10.1016/J.ACA.2015.09.024

Megan K. Thorson, Ryan M. Van Wagoner, Mary Kay Harper, Chris M. Ireland, Tomas Majtan, Jan P. Kraus, Amy M. Barrios. (2015). Marine natural products as inhibitors of cystathionine beta-synthase activity. Bioorganic & Medicinal Chemistry Letters, 25(5):1064-1066. doi: 10.1016/J.BMCL.2015.01.013

Megan K. Thorson, David T. Puerta, Seth M. Cohen, Amy M. Barrios. (2014). Inhibition of the Lymphoid Tyrosine Phosphatase: The Effect of Zinc(II) ions and Chelating Ligand Fragments on Enzymatic Activity. Bioorganic & Medicinal Chemistry Letters, 24(16):4019-4022. doi: 10.1016/J.BMCL.2014.06.016

Ziqing Qian, Jonathan R. LaRochelle, Bisheng Jiang, Wenlong Lian, Ryan L. Hard, Nicholas G. Selner, Rinrada Luechapanichkul, Amy M. Barrios, Dehua Pei. (2014). Early endosomal escape of a cyclic cell-penetrating peptide allows effective cytosolic cargo delivery. Biochemistry, 53(24):4034-4046. doi: 10.1021/BI5004102

Stephanie M. Stanford, Vanessa Ahmed, Amy M. Barrios, Nunzio Bottini. (2014). Cellular biochemistry methods for investigating protein tyrosine phosphatases. Antioxidants & Redox Signaling, 20(14):2160-2178. doi: 10.1089/ARS.2013.5731

Elizabeth R. Sharlow, Stephanie Leimgruber, Samantha Murray, Ana Lira, Richard J. Sciotti, Mark Hickman, Thomas H. Hudson, Susan E. Leed, Diana Caridha, Amy M. Barrios, David A. Close, Max Grogl, John S. Lazo. (2014). Auranofin Is an Apoptosis-Simulating Agent with in Vitro and in Vivo Anti-leishmanial Activity. ACS Chemical Biology, 9(3):663-672. doi: 10.1021/CB400800Q

Vanessa Ahmed, Nunzio Bottini, Amy M. Barrios. (2014). Covalent Inhibition of the Lymphoid Tyrosine Phosphatase. ChemMedChem, 9(2):296-299. doi: 10.1002/CMDC.201300404

Stephanie M. Stanford, Divya Krishnamurthy, Rhushikesh A. Kulkarni, Caitlin E. Karver, Eveline Bruenger, Logan M. Walker, Chen Ting Ma, Thomas D.Y. Chung, Eduard Sergienko, Nunzio Bottini, Amy M. Barrios. (2014). pCAP-based peptide substrates: the new tool in the box of tyrosine phosphatase assays. Methods, 65(2):165-174. doi: 10.1016/J.YMETH.2013.07.022

Rhushikesh A. Kulkarni, Nadeem A. Vellore, Matthew R. Bliss, Stephanie M. Stanford, Matthew D. Falk, Nunzio Bottini, Riccardo, Baron Amy M. Barrios. (2013). Substrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitors. ChemBioChem, 14(13):1640-1647. doi: 10.1002/CBIC.201300273

Rhushikesh A. Kulkarni, Stephanie M. Stanford, Nadeem A. Vellore, Divya Krishnamurthy, Matthew R. Bliss, Riccardo, Baron Nunzio Bottini, Amy M. Barrios. (2013). Thiuram Disulfides as Pseudo‐irreversible Inhibitors of Lymphoid Tyrosine Phosphatase. ChemMedChem, 8(9):1561-1568. doi: 10.1002/CMDC.201300215

Yantao He, Sijiu Liu, Ambili Menon, Stephanie M. Stanford, Emmanuel Oppong, Andrea M. Gunawan, Li Wu, Dennis J. Wu, Amy M. Barrios, Nunzio Bottini, Andrew C.B. Cato, Zhong-Yin Zhang. (2013). A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases. Journal of Medicinal Chemistry, 56(12):4990-5008. doi: 10.1021/JM400248C

Amy M. Barrios, Seth M. Cohen, Mi Hee Lim. (2013). Medicinal inorganic chemistry: a web themed issue. Chemical Communications. 49(53):5910-5911. doi: 10.1039/C3CC90159A

Megan K. Thorson, Tomas Majtan, Jan P. Kraus, Amy M. Barrios. (2013). Identification of Cystathionine β‐Synthase Inhibitors Using a Hydrogen Sulfide Selective Probe. Angewandte Chemie, 52(17):4641-4644. doi: 10.1002/ANIE.201300841

Ziqing Qian, Tao Liu, Yu-Yu Liu, Roger Briesewitz, Amy M. Barrios, Sissy M. Jhiang, Dehua Pei. (2013). Efficient delivery of cyclic peptides into mammalian cells with short sequence motifs. ACS Chemical Biology, 8(2):423-431. doi: 10.1021/CB3005275

Stephanie M. Stanford, Rekha G. Panchal, Logan M. Walker, Dennis J. Wu, Matthew D. Falk, Sayantan Mitra, Sagar S. Damle, David Ruble, Teodora Kaltcheva, Sheng Zhang, Zhong-Yin Zhang, Sina Bavari, Amy M. Barrios, Nunzio Bottini. (2012). High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45. Proceedings of the National Academy of Sciences of the United States of America, 109(35):13972-13977. doi: 10.1073/PNAS.1205028109

Anjan Debnath, Derek Parsonage, Rosa M. Andrade, Chen-chen He, Eduardo R. Cobo, Ken-ichi Hirata, Steven Chen, Guillermina García-Rivera, Esther Orozco, Máximo B. Martínez, Shamila S. Gunatilleke, Amy M. Barrios, Michelle R. Arkin, Leslie B. Poole, James H. McKerrow, Sharon L. Reed. (2012). A high throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nature Medicine, 18(6):956-960. doi: 10.1038/NM.2758

David D. Obiri, N. Flink, Jana V. Maier, Antje Neeb, Danilo Maddalo, Wilko Thiele A. Menon, Michael Stassen, Rhushikesh A. Kulkarni, M. J. Garabedian, Amy M. Barrios, Andrew C.B. Cato. (2012). PEST-domain-enriched tyrosine phosphatase and glucocorticoids as regulators of anaphylaxis in mice. Allergy, 67(2):175-182. doi: 10.1111/J.1398-9995.2011.02731.X

Stephanie M. Stanford, Divya Krishnamurthy, Matthew D. Falk, Rossella Messina, Bikash Debnath, Sheng Li, Tong Liu, Roza Kazemi, Russell Dahl, Yantao He, Xiao Yu, Andrew C. Chan, Zhong-Yin, Zhang, Amy M. Barrios, Virgil L. Woods, Nouri Neamati, Nunzio Bottini. (2011). Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. Journal of Medicinal Chemistry, 54(6):1640-1654. doi: 10.1021/JM101202J

Caitlin E. Karver, Vanessa Ahmed, Amy M. Barrios. (2010). Oxidative inactivation of the lymphoid tyrosine phosphatase mediated by both general and active site directed NO donors. Bioorganic & Medicinal Chemistry Letters, 21(1):285-287. doi: 10.1016/J.BMCL.2010.11.025

Mark R. Karver, Divya Krishnamurthy, Nunzio Bottini, Amy M. Barrios. (2010). Gold(I) phosphine mediated selective inhibition of lymphoid tyrosine phosphatase. Journal of Inorganic Biochemistry, 104(3):268-273. doi: 10.1016/J.JINORGBIO.2009.12.012

Mark R. Karver, Divya Krishnamurthy, Rhushikesh A. Kulkarni, Nunzio Bottini, Amy M. Barrios. (2009). Identifying Potent, Selective Protein Tyrosine Phosphatase Inhibitors from a Library of Au(I) Complexes. Journal of Medicinal Chemistry, 52(21):6912-6918. doi: 10.1021/JM901220M

Divya Krishnamurthy, Amy M. Barrios. (2009). Profiling protein tyrosine phosphatase activity with mechanistic probes. Current Opinion in Chemical Biology, 13(4):375-381. doi: 10.1016/J.CBPA.2009.07.017

Mark R. Karver, Amy M. Barrios. (2008). Identifying and characterizing the biological targets of metallotherapeutics: Two approaches using Au(I)-protein interactions as model systems. Analytical Biochemistry, 382(1):63-65. doi: 10.1016/J.AB.2008.07.019

Divya Krishnamurthy, Mark R. Karver, Edoardo Fiorillo, Valeria Orrù, Stephanie M. Stanford, Nunzio Bottini, Amy M. Barrios. (2008). Gold(I)-Mediated Inhibition of Protein Tyrosine Phosphatases: A Detailed in Vitro and Cellular Study. Journal of Medicinal Chemistry, 51(15):4790-4795. doi: 10.1021/JM800101W

Caitlin E. Hubbard, Amy M. Barrios. (2008). A Highly Efficient Route to Enantiomerically Pure L-N-Bz-Pmp(t-Bu)2-OH and Incorporation into a Peptide-Based Protein Tyrosine Phosphatase Inhibitor. ChemInform, 39(25) doi: 10.1002/CHIN.200825176

Sayantan Mitra, Amy M. Barrios. (2008). Identifying selective protein tyrosine phosphatase substrates and inhibitors from a fluorogenic, combinatorial peptide library. ChemBioChem, 9(8):1216-1219. doi: 10.1002/CBIC.200800046

Matthew A. Franzman, Amy M. Barrios. (2008). Spectroscopic Evidence for the Formation of Goldfingers. Inorganic Chemistry, 47(10):3928-3930. doi: 10.1021/IC800157T

Shamila S. Gunatilleke, Amy M. Barrios. (2008). Tuning the Au(I)-mediated inhibition of cathepsin B through ligand substitutions. Journal of Inorganic Biochemistry, 102(3):555-563. doi: 10.1016/J.JINORGBIO.2007.10.019

Shamila S. Gunatilleke, César Augusto F. de Oliveira, J. Andrew McCammon, Amy M. Barrios. (2008). Inhibition of cathepsin B by Au(I) complexes: a kinetic and computational study. Journal of Biological Inorganic Chemistry. 13(4):555-561. doi: 10.1007/S00775-008-0344-0

Caitlin E. Hubbard, Amy M. Barrios. (2008). A Highly Efficient Route to Enantiomerically Pure l-N-Bz-Pmp(t-Bu)2-OH and Incorporation into a Peptide-Based Protein Tyrosine Phosphatase Inhibitor. Bioorganic & Medicinal Chemistry Letters, 18(2):679-681. doi: 10.1016/J.BMCL.2007.11.056

Sayantan Mitra, Amy M. Barrios. (2007). A series of peptide-based, fluorogenic probes for protein tyrosine phosphatase activity. Analytical Biochemistry, 370(2):249-251. doi: 10.1016/J.AB.2007.06.012

Sayantan Mitra, Amy M. Barrios. (2006). Coumarin-based amino acids for use in enzyme activity and substrate specificity assays.

Shamila S. Gunatilleke, Amy M. Barrios. (2006). Inhibition of lysosomal cysteine proteases by a series of Au(I) complexes: A detailed mechanistic investigation. Journal of Medicinal Chemistry, 49(13):3933-3937. doi: 10.1021/JM060158F

Amy M. Barrios. (2006). Intracellular Metal Detectors. ACS Chemical Biology, 1(2):67-68. doi: 10.1021/CB600080A

Sayantan Mitra, Amy M. Barrios. (2006). Highly Sensitive Peptide‐Based Probes for Protein Tyrosine Phosphatase Activity Utilizing a Fluorogenic Mimic of Phosphotyrosine. ChemInform, 37(9) doi: 10.1002/CHIN.200609200

Sayantan Mitra, Amy M. Barrios. (2005). Highly sensitive peptide-based probes for protein tyrosine phosphatase activity utilizing a fluorogenic mimic of phosphotyrosine. Bioorganic & Medicinal Chemistry Letters, 15(23):5142-5145. doi: 10.1016/J.BMCL.2005.08.054

Aida Chircorian, Amy M. Barrios. (2004). Inhibition of lysosomal cysteine proteases by chrysotherapeutic compounds: a possible mechanism for the antiarthritic activity of Au(I). Bioorganic & Medicinal Chemistry Letters, 14(20):5113-5116. doi: 10.1016/J.BMCL.2004.07.073

Amy M. Barrios, Charles S. Craik. (2002). Scanning the prime-site substrate specificity of proteolytic enzymes: a novel assay based on ligand-enhanced lanthanide ion fluorescence. Bioorganic & Medicinal Chemistry Letters, 12(24):3619-3623. doi: 10.1016/S0960-894X(02)00786-2

Amy M. Barrios, Stephen J. Lippard. (2001). Decomposition of alkyl-substituted urea molecules at a hydroxide-bridged dinickel center. Inorganic Chemistry, 40(6):1250-1255. doi: 10.1021/IC000933W

Amy M. Barrios, Stephen J. Lippard. (2001). Phthalazine-based dinucleating ligands afford dinuclear centers often encountered in metalloenzyme active sites. Inorganic Chemistry, 40(5):1060-1064. doi: 10.1021/IC000889K

Chuan He, Amy M. Barrios, Dongwhan Lee, Jane Kuzelka, and, Roman M. Davydov, Stephen J. Lippard. (2000). Diiron Complexes of 1,8-Naphthyridine-Based Dinucleating Ligands as Models for Hemerythrin. Journal of the American Chemical Society, 122(51):12683-12690. doi: 10.1021/JA0026861

Amy M. Barrios, Stephen J. Lippard. (2000). Interaction of Urea with a Hydroxide-Bridged Dinuclear Nickel Center: An Alternative Model for the Mechanism of Urease. Journal of the American Chemical Society, 122(38):9172-9177. doi: 10.1021/JA000202V

Amy M. Barrios, Stephen J. Lippard. (1999). Amide Hydrolysis Effected by a Hydroxo-Bridged Dinickel(II) Complex: Insights into the Mechanism of Urease. Journal of the American Chemical Society, 121(50):11751-11757. doi: 10.1021/JA992447H

Daniel D. LeCloux, Amy M. Barrios, Stephen J. Lippard. (1999). The reactivity of well defined diiron(III) peroxo complexes toward substrates: addition to electrophiles and hydrocarbon oxidation. Bioorganic & Medicinal Chemistry, 7(5):763-772. doi: 10.1016/S0968-0896(98)00270-3

Daniel D. LeCloux, Amy M. Barrios, Tadashi J. Mizoguchi, Stephen J. Lippard. (1998). Modeling the Diiron Centers of Non-Heme Iron Enzymes. Preparation of Sterically Hindered Diiron(II) Tetracarboxylate Complexes and Their Reactions with Dioxygen. Journal of the American Chemical Society, 120(35):9001-9014. doi: 10.1021/JA981216S

Gang Liu, Fred W. Bruenger, Amy M. Barrios, Scott C. Miller. (1996). Synthesis of 2‐Alkyl‐3‐hydroxy‐4‐pyridinone‐ribonucleosides, Potential Oral Iron Chelators. ChemInform, 27(16) doi: 10.1002/CHIN.199616257

Gang Liu, Fred W. Bruenger, Amy M. Barrios, Scott C. Miller. (1995). Synthesis of 2-Alkyl-3-hydroxy-4-pyridinone-ribonucleosides, Potential Oral Iron Chelators. Nucleosides, Nucleotides & Nucleic Acids, 14:1901-1904. doi: 10.1080/15257779508010712