Publications
Brandon S. McCullough, Hanfei Wang, and Amy M. Barrios. (2022).
Inhibitor Screen Identifies Covalent Inhibitors of the Protein Histidine
Phosphatase PHPT1. ACS Medicinal Chemistry Letters
13 (7), 1198-1201 DOI: 10.1021/a
csmedchemlett.2c00053
Matthew R. Blake, Ryan T. Gardner, Haihong Jin, Melanie A. Staffenson,
Nicole J. Rueb, Amy M. Barrios, Gregory B. Dudley, Michael S. Cohen*,
and Beth A. Habecker. (2022). Small Molecules Targeting PTPσ–Trk
Interactions Promote Sympathetic Nerve Regeneration. ACS Chemical
Neuroscience, 13(5), 688-699.
Harvey F. Fulo, Nicole J. Rueb, Robert Gaston, Paratchata Batsomboon,
Kh Tanvir Ahmed, Amy M. Barrios, Gregory B. Dudley. (2021). Synthesis of
illudalic acid and analogous phosphatase inhibitors. Organic and
Biomolecular Chemistry, doi: 10.1039/D1OB02106K
Cheryl L. Mathis, Amy M. Barrios. (2021). Histidine phosphorylation
in metalloprotein binding sites. Journal of Inorganic Biochemistry,
225:111606-. doi: 10.1016/J.JINORGBIO.2021.111606
Amy M. Barrios. (2020). PTPs: Degrading the Undruggable. Journal of Medicinal Chemistry, 63(14):7508-7509. doi: 10.1021/ACS.JMEDCHEM.0C01000
Brandon S. McCullough, Amy M. Barrios. (2020). Fluorogenic probes for imaging cellular phosphatase activity. Current Opinion in Chemical Biology, 57:34-40. doi: 10.1016/J.CBPA.2020.04.004
Brandon S. McCullough, Amy M. Barrios. (2019). In Vitro Assays for Measuring Protein Histidine Phosphatase Activity. Methods of Molecular Biology, 2077:109-120. doi: 10.1007/978-1-4939-9884-5_8
Brandon S. McCullough, Paratchata Batsomboon, Kacey B. Hutchinson, Gregory B. Dudley, Amy M. Barrios. (2019). Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions. Journal of Natural Products, 82(12):3386-3393. doi: 10.1021/ACS.JNATPROD.9B00663
Elena S. Ma, Amy M. Barrios. (2019). Rational design of a SHP-2 targeted, fluorogenic peptide substrate. Bioorganic & Medicinal Chemistry Letters, 29(17):2452-2454. doi: 10.1016/J.BMCL.2019.07.034
Brandon S. McCullough, Amy M. Barrios. (2018). Facile, Fluorogenic Assay for Protein Histidine Phosphatase Activity. Biochemistry, 57(18):2584-2589. doi: 10.1021/ACS.BIOCHEM.8B00278
Margaret L. Aulsebrook, Suvendu Biswas, Franklin M. Leaver, Michael R. Grace, Bim Graham, Amy M. Barrios, Kellie L. Tuck. (2017). A luminogenic lanthanide-based probe for the highly selective detection of nanomolar sulfide levels in aqueous samples. Chemical Communications, 53(36):4911-4914. doi: 10.1039/C7CC01764B
Suvendu Biswas, Brandon S. McCullough, Elena S. Ma, Dollie LaJoie, Colin W. Russell, D. Garrett Brown, June L. Round, Katharine S. Ullman, Matthew A. Mulvey, Amy M. Barrios. (2017). Dual colorimetric and fluorogenic probes for visualizing tyrosine phosphatase activity. Chemical Communications, 53(14):2233-2236. doi: 10.1039/C6CC09204G
Amy M. Barrios, Megan K. Thorson, Kellie L. Tuck, Graham Bim. (2016). Chemical probes for hydrogen sulfide.
Megan K. Thorson, Phuc, Ung, Franklin, M, Leaver, Teresa, S, Corbin, Kellie L. Tuck, Bim Graham, Amy M. Barrios. (2015). Lanthanide complexes as luminogenic probes to measure sulfide levels in industrial samples. Analytica Chimica Acta, 896:160-165. doi: 10.1016/J.ACA.2015.09.024
Megan K. Thorson, Ryan M. Van Wagoner, Mary Kay Harper, Chris M. Ireland, Tomas Majtan, Jan P. Kraus, Amy M. Barrios. (2015). Marine natural products as inhibitors of cystathionine beta-synthase activity. Bioorganic & Medicinal Chemistry Letters, 25(5):1064-1066. doi: 10.1016/J.BMCL.2015.01.013
Megan K. Thorson, David T. Puerta, Seth M. Cohen, Amy M. Barrios. (2014). Inhibition of the Lymphoid Tyrosine Phosphatase: The Effect of Zinc(II) ions and Chelating Ligand Fragments on Enzymatic Activity. Bioorganic & Medicinal Chemistry Letters, 24(16):4019-4022. doi: 10.1016/J.BMCL.2014.06.016
Ziqing Qian, Jonathan R. LaRochelle, Bisheng Jiang, Wenlong Lian, Ryan L. Hard, Nicholas G. Selner, Rinrada Luechapanichkul, Amy M. Barrios, Dehua Pei. (2014). Early endosomal escape of a cyclic cell-penetrating peptide allows effective cytosolic cargo delivery. Biochemistry, 53(24):4034-4046. doi: 10.1021/BI5004102
Stephanie M. Stanford, Vanessa Ahmed, Amy M. Barrios, Nunzio Bottini. (2014). Cellular biochemistry methods for investigating protein tyrosine phosphatases. Antioxidants & Redox Signaling, 20(14):2160-2178. doi: 10.1089/ARS.2013.5731
Elizabeth R. Sharlow, Stephanie Leimgruber, Samantha Murray, Ana Lira, Richard J. Sciotti, Mark Hickman, Thomas H. Hudson, Susan E. Leed, Diana Caridha, Amy M. Barrios, David A. Close, Max Grogl, John S. Lazo. (2014). Auranofin Is an Apoptosis-Simulating Agent with in Vitro and in Vivo Anti-leishmanial Activity. ACS Chemical Biology, 9(3):663-672. doi: 10.1021/CB400800Q
Vanessa Ahmed, Nunzio Bottini, Amy M. Barrios. (2014). Covalent Inhibition of the Lymphoid Tyrosine Phosphatase. ChemMedChem, 9(2):296-299. doi: 10.1002/CMDC.201300404
Stephanie M. Stanford, Divya Krishnamurthy, Rhushikesh A. Kulkarni, Caitlin E. Karver, Eveline Bruenger, Logan M. Walker, Chen Ting Ma, Thomas D.Y. Chung, Eduard Sergienko, Nunzio Bottini, Amy M. Barrios. (2014). pCAP-based peptide substrates: the new tool in the box of tyrosine phosphatase assays. Methods, 65(2):165-174. doi: 10.1016/J.YMETH.2013.07.022
Rhushikesh A. Kulkarni, Nadeem A. Vellore, Matthew R. Bliss, Stephanie M. Stanford, Matthew D. Falk, Nunzio Bottini, Riccardo, Baron Amy M. Barrios. (2013). Substrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitors. ChemBioChem, 14(13):1640-1647. doi: 10.1002/CBIC.201300273
Rhushikesh A. Kulkarni, Stephanie M. Stanford, Nadeem A. Vellore, Divya Krishnamurthy, Matthew R. Bliss, Riccardo, Baron Nunzio Bottini, Amy M. Barrios. (2013). Thiuram Disulfides as Pseudo‐irreversible Inhibitors of Lymphoid Tyrosine Phosphatase. ChemMedChem, 8(9):1561-1568. doi: 10.1002/CMDC.201300215
Yantao He, Sijiu Liu, Ambili Menon, Stephanie M. Stanford, Emmanuel Oppong, Andrea M. Gunawan, Li Wu, Dennis J. Wu, Amy M. Barrios, Nunzio Bottini, Andrew C.B. Cato, Zhong-Yin Zhang. (2013). A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases. Journal of Medicinal Chemistry, 56(12):4990-5008. doi: 10.1021/JM400248C
Amy M. Barrios, Seth M. Cohen, Mi Hee Lim. (2013). Medicinal inorganic chemistry: a web themed issue. Chemical Communications. 49(53):5910-5911. doi: 10.1039/C3CC90159A
Megan K. Thorson, Tomas Majtan, Jan P. Kraus, Amy M. Barrios. (2013). Identification of Cystathionine β‐Synthase Inhibitors Using a Hydrogen Sulfide Selective Probe. Angewandte Chemie, 52(17):4641-4644. doi: 10.1002/ANIE.201300841
Ziqing Qian, Tao Liu, Yu-Yu Liu, Roger Briesewitz, Amy M. Barrios, Sissy M. Jhiang, Dehua Pei. (2013). Efficient delivery of cyclic peptides into mammalian cells with short sequence motifs. ACS Chemical Biology, 8(2):423-431. doi: 10.1021/CB3005275
Stephanie M. Stanford, Rekha G. Panchal, Logan M. Walker, Dennis J. Wu, Matthew D. Falk, Sayantan Mitra, Sagar S. Damle, David Ruble, Teodora Kaltcheva, Sheng Zhang, Zhong-Yin Zhang, Sina Bavari, Amy M. Barrios, Nunzio Bottini. (2012). High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45. Proceedings of the National Academy of Sciences of the United States of America, 109(35):13972-13977. doi: 10.1073/PNAS.1205028109
Anjan Debnath, Derek Parsonage, Rosa M. Andrade, Chen-chen He, Eduardo R. Cobo, Ken-ichi Hirata, Steven Chen, Guillermina García-Rivera, Esther Orozco, Máximo B. Martínez, Shamila S. Gunatilleke, Amy M. Barrios, Michelle R. Arkin, Leslie B. Poole, James H. McKerrow, Sharon L. Reed. (2012). A high throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nature Medicine, 18(6):956-960. doi: 10.1038/NM.2758
David D. Obiri, N. Flink, Jana V. Maier, Antje Neeb, Danilo Maddalo, Wilko Thiele A. Menon, Michael Stassen, Rhushikesh A. Kulkarni, M. J. Garabedian, Amy M. Barrios, Andrew C.B. Cato. (2012). PEST-domain-enriched tyrosine phosphatase and glucocorticoids as regulators of anaphylaxis in mice. Allergy, 67(2):175-182. doi: 10.1111/J.1398-9995.2011.02731.X
Stephanie M. Stanford, Divya Krishnamurthy, Matthew D. Falk, Rossella Messina, Bikash Debnath, Sheng Li, Tong Liu, Roza Kazemi, Russell Dahl, Yantao He, Xiao Yu, Andrew C. Chan, Zhong-Yin, Zhang, Amy M. Barrios, Virgil L. Woods, Nouri Neamati, Nunzio Bottini. (2011). Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. Journal of Medicinal Chemistry, 54(6):1640-1654. doi: 10.1021/JM101202J
Caitlin E. Karver, Vanessa Ahmed, Amy M. Barrios. (2010). Oxidative inactivation of the lymphoid tyrosine phosphatase mediated by both general and active site directed NO donors. Bioorganic & Medicinal Chemistry Letters, 21(1):285-287. doi: 10.1016/J.BMCL.2010.11.025
Mark R. Karver, Divya Krishnamurthy, Nunzio Bottini, Amy M. Barrios. (2010). Gold(I) phosphine mediated selective inhibition of lymphoid tyrosine phosphatase. Journal of Inorganic Biochemistry, 104(3):268-273. doi: 10.1016/J.JINORGBIO.2009.12.012
Mark R. Karver, Divya Krishnamurthy, Rhushikesh A. Kulkarni, Nunzio Bottini, Amy M. Barrios. (2009). Identifying Potent, Selective Protein Tyrosine Phosphatase Inhibitors from a Library of Au(I) Complexes. Journal of Medicinal Chemistry, 52(21):6912-6918. doi: 10.1021/JM901220M
Divya Krishnamurthy, Amy M. Barrios. (2009). Profiling protein tyrosine phosphatase activity with mechanistic probes. Current Opinion in Chemical Biology, 13(4):375-381. doi: 10.1016/J.CBPA.2009.07.017
Divya Krishnamurthy, Amy M. Barrios. (2009). Profiling protein tyrosine phosphatase activity with mechanistic probes. Current Opinion in Chemical Biology, 13(4):375-381. doi: 10.1016/J.CBPA.2009.07.017
Mark R. Karver, Amy M. Barrios. (2008). Identifying and characterizing the biological targets of metallotherapeutics: Two approaches using Au(I)-protein interactions as model systems. Analytical Biochemistry, 382(1):63-65. doi: 10.1016/J.AB.2008.07.019
Divya Krishnamurthy, Mark R. Karver, Edoardo Fiorillo, Valeria Orrù, Stephanie M. Stanford, Nunzio Bottini, Amy M. Barrios. (2008). Gold(I)-Mediated Inhibition of Protein Tyrosine Phosphatases: A Detailed in Vitro and Cellular Study. Journal of Medicinal Chemistry, 51(15):4790-4795. doi: 10.1021/JM800101W
Caitlin E. Hubbard, Amy M. Barrios. (2008). A Highly Efficient Route to Enantiomerically Pure L-N-Bz-Pmp(t-Bu)2-OH and Incorporation into a Peptide-Based Protein Tyrosine Phosphatase Inhibitor. ChemInform, 39(25) doi: 10.1002/CHIN.200825176
Sayantan Mitra, Amy M. Barrios. (2008). Identifying selective protein tyrosine phosphatase substrates and inhibitors from a fluorogenic, combinatorial peptide library. ChemBioChem, 9(8):1216-1219. doi: 10.1002/CBIC.200800046
Matthew A. Franzman, Amy M. Barrios. (2008). Spectroscopic Evidence for the Formation of Goldfingers. Inorganic Chemistry, 47(10):3928-3930. doi: 10.1021/IC800157T
Shamila S. Gunatilleke, Amy M. Barrios. (2008). Tuning the Au(I)-mediated inhibition of cathepsin B through ligand substitutions. Journal of Inorganic Biochemistry, 102(3):555-563. doi: 10.1016/J.JINORGBIO.2007.10.019
Shamila S. Gunatilleke, César Augusto F. de Oliveira, J. Andrew McCammon, Amy M. Barrios. (2008). Inhibition of cathepsin B by Au(I) complexes: a kinetic and computational study. Journal of Biological Inorganic Chemistry. 13(4):555-561. doi: 10.1007/S00775-008-0344-0
Caitlin E. Hubbard, Amy M. Barrios. (2008). A Highly Efficient Route to Enantiomerically Pure l-N-Bz-Pmp(t-Bu)2-OH and Incorporation into a Peptide-Based Protein Tyrosine Phosphatase Inhibitor. Bioorganic & Medicinal Chemistry Letters, 18(2):679-681. doi: 10.1016/J.BMCL.2007.11.056
Sayantan Mitra, Amy M. Barrios. (2007). A series of peptide-based, fluorogenic probes for protein tyrosine phosphatase activity. Analytical Biochemistry, 370(2):249-251. doi: 10.1016/J.AB.2007.06.012
Sayantan Mitra, Amy M. Barrios. (2006). Coumarin-based amino acids for use in enzyme activity and substrate specificity assays.
Shamila S. Gunatilleke, Amy M. Barrios. (2006). Inhibition of lysosomal cysteine proteases by a series of Au(I) complexes: A detailed mechanistic investigation. Journal of Medicinal Chemistry, 49(13):3933-3937. doi: 10.1021/JM060158F
Amy M. Barrios. (2006). Intracellular Metal Detectors. ACS Chemical Biology, 1(2):67-68. doi: 10.1021/CB600080A
Sayantan Mitra, Amy M. Barrios. (2006). Highly Sensitive Peptide‐Based Probes for Protein Tyrosine Phosphatase Activity Utilizing a Fluorogenic Mimic of Phosphotyrosine. ChemInform, 37(9) doi: 10.1002/CHIN.200609200
Sayantan Mitra, Amy M. Barrios. (2005). Highly sensitive peptide-based probes for protein tyrosine phosphatase activity utilizing a fluorogenic mimic of phosphotyrosine. Bioorganic & Medicinal Chemistry Letters, 15(23):5142-5145. doi: 10.1016/J.BMCL.2005.08.054
Aida Chircorian, Amy M. Barrios. (2004). Inhibition of lysosomal cysteine proteases by chrysotherapeutic compounds: a possible mechanism for the antiarthritic activity of Au(I). Bioorganic & Medicinal Chemistry Letters, 14(20):5113-5116. doi: 10.1016/J.BMCL.2004.07.073
Amy M. Barrios, Charles S. Craik. (2002). Scanning the prime-site substrate specificity of proteolytic enzymes: a novel assay based on ligand-enhanced lanthanide ion fluorescence. Bioorganic & Medicinal Chemistry Letters, 12(24):3619-3623. doi: 10.1016/S0960-894X(02)00786-2
Amy M. Barrios, Stephen J. Lippard. (2001). Decomposition of alkyl-substituted urea molecules at a hydroxide-bridged dinickel center. Inorganic Chemistry, 40(6):1250-1255. doi: 10.1021/IC000933W
Amy M. Barrios, Stephen J. Lippard. (2001). Phthalazine-based dinucleating ligands afford dinuclear centers often encountered in metalloenzyme active sites. Inorganic Chemistry, 40(5):1060-1064. doi: 10.1021/IC000889K
Chuan He, Amy M. Barrios, Dongwhan Lee, Jane Kuzelka, and, Roman M. Davydov, Stephen J. Lippard. (2000). Diiron Complexes of 1,8-Naphthyridine-Based Dinucleating Ligands as Models for Hemerythrin. Journal of the American Chemical Society, 122(51):12683-12690. doi: 10.1021/JA0026861
Amy M. Barrios, Stephen J. Lippard. (2000). Interaction of Urea with a Hydroxide-Bridged Dinuclear Nickel Center: An Alternative Model for the Mechanism of Urease. Journal of the American Chemical Society, 122(38):9172-9177. doi: 10.1021/JA000202V
Amy M. Barrios, Stephen J. Lippard. (1999). Amide Hydrolysis Effected by a Hydroxo-Bridged Dinickel(II) Complex: Insights into the Mechanism of Urease. Journal of the American Chemical Society, 121(50):11751-11757. doi: 10.1021/JA992447H
Daniel D. LeCloux, Amy M. Barrios, Stephen J. Lippard. (1999). The reactivity of well defined diiron(III) peroxo complexes toward substrates: addition to electrophiles and hydrocarbon oxidation. Bioorganic & Medicinal Chemistry, 7(5):763-772. doi: 10.1016/S0968-0896(98)00270-3
Daniel D. LeCloux, Amy M. Barrios, Tadashi J. Mizoguchi, Stephen J. Lippard. (1998). Modeling the Diiron Centers of Non-Heme Iron Enzymes. Preparation of Sterically Hindered Diiron(II) Tetracarboxylate Complexes and Their Reactions with Dioxygen. Journal of the American Chemical Society, 120(35):9001-9014. doi: 10.1021/JA981216S
Gang Liu, Fred W. Bruenger, Amy M. Barrios, Scott C. Miller. (1996). Synthesis of 2‐Alkyl‐3‐hydroxy‐4‐pyridinone‐ribonucleosides, Potential Oral Iron Chelators. ChemInform, 27(16) doi: 10.1002/CHIN.199616257
Gang Liu, Fred W. Bruenger, Amy M. Barrios, Scott C. Miller. (1995). Synthesis of 2-Alkyl-3-hydroxy-4-pyridinone-ribonucleosides, Potential Oral Iron Chelators. Nucleosides, Nucleotides & Nucleic Acids, 14:1901-1904. doi: 10.1080/15257779508010712